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KMID : 0363320010220040633
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Journal of Korean Oriental Internal Medicine
2001 Volume.22 No. 4 p.633 ~ p.638
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Safety and Effect of Oriental Medicine and Continuous Intravenous Urokinase combined Therapy in Acute Ischemic Stroke(open clinical trial)
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Lee Beom-Jun
Kim Tae-Yeon
Jo Young
Lee Jun-Hee
Lew Jae-Hwan
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Abstract
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Objective : Stroke is the most frequent cause of death in Korea. Because it remains severe disablities disturbing normal life, it is important to carry out intervention preventing from progression of condition in patients with acute ischemic stroke within therapeutic time window. Thus early thrombolysis is beneficial for patients with acute ischemic stroke. However its therapeutic efficacy is not known in combination with oriental medical therapy. In this study, we investigated the safety and the clinical effect of continous intravenous urokinase therapy and oriental medical therapy.
Methods : Twenty eight patients with acute onset of ischemic stroke no later than three days received continous infusion of urokinase and oriental medical therapy. We estimated the subjects’s neurological deficit and functional status with National institute of Neurologic Disorders and Stroke Scale(NIHSS) and Europian Stroke Scale (ESS) prior to therapy, on day 3, 7, 14 after the starting urokinase therapy and on day at discharge.
Results: After day 7, the scores of NIHSS and ESS were improved significantly. There are no differences in therapeutic effects of the interval between onset of stroke and initiation of therapy. Complication were noted in four(14%) patients, but these are not fatal complication and make no neurological deficiency.
Conclusion : The results of these investment suggest that continuous intravenous urokinase with oriental medical therapy could be a safe and effective intervention to prevent from progression in acute ischemic stroke. But this findings should be confirmed in multicenter double blind controlled trial.
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KEYWORD
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urokinase, Thrombolysis, Acute ischemic stroke, Oriental Medicine
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